Research Study Aimed at Understanding Chemotherapy and Hormone Depletion Effects

Research Study Aimed at Understanding how Chemotherapy and Hormone Depletion Affect Memory and Cognition in Breast Cancer Survivors

The Department of Medical Social Sciences at Northwestern University would like to invite a group of motivated survivors to participate in a research study examining the effects of chemotherapy and hormone depletion therapy on memory and cognition. (NU IRB Study Number: STU#00070091)

• Prior research has indicated that up to 90% of chemotherapy recipients also receiving hormone depletion therapy (such as Tamoxifen) report disruptions in cognition such as memory, attention, and planning. The purpose of our research is to help find out what happens to the brain that leads to these disruptions.

• This research will utilize a method known as functional magnetic resonance imaging (fMRI) to record the activity of your brain. MRI is very safe. It is a completely non-invasive procedure. This means that no needles, chemicals, or radiation are used in the procedure. You will be asked to perform basic tasks, which may require you to respond to visual stimuli presented on a computer screen.

Additional eligibility criteria for participation:
• You cannot currently be pregnant
• You must be right handed
• You must be between 18 and 45 years of age
• You must have received chemotherapy treatment with hormone depletion therapy in the last 6-12 months
• You cannot have certain implants or devices that are metallic in your body. MRI machines use a strong magnetic field, and metallic objects may be hazardous and/or interfere with the procedure.

• You will receive $60.00 for your participation and be reimbursed for travel expenses
• This study will take approximately two hours
• This study will take place at the Northwestern University Feinberg School of Medicine in Chicago
• If interested, please email or call 312-503-5613

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